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This equivalence in average topologies of denatured states explains why it has been reasonable to ignore the denatured state when assessing the contribution of topology to folding rates for small two-state proteins valtrex pregnant .
with T^sub m^ close to 330 K (Fig valtrex pregnant .
1 A) and the maximum wavelength of the emission spectra moved toward higher values (data not shown), indicating solvent exposure of the fluorescence residues valtrex pregnant .
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5), the entropy buildup curves show a substantial jump at the appending point when the trajectory of the free form is appended to that of the complex form (dashed line), indicating that the free molecule samples conformational space not visited in the complex simulation (case A; Fig valtrex pregnant .
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