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- Source: Georgia Tech College of Management's Financial Analysis Lab
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. ApoA-2 has particularly large apolar helical faces (50% of the surface as compared to ~30% in apoA-1 and apoC-1) which, along with higher hydrophobicity of these faces, is thought to account for stronger association of apoA-2 with HDL (Brasseur et al
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. In summary, chemical denaturation of discoidal lipoproteins is a complex multiphase transition whose kinetics is distinctly different from that of the thermal denaturation; similar to thermal denaturation, chemical denaturation involves protein unfolding/dissociation (Reijngoud and Phillips, 1982) and lipoprotein fusion (Fig
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. In the hypergutter picture, the nine-dimensional search space of these critical regions separately is reduced to three sequential three-dimensional searches by the long lifetimes of the native regions when the remainder of the protein is disordered
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