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These hierarchical distance distributions reflect the so-called dilatation symmetry in the EV limit whereby contact density maps for one protein sequence can be rescaled to obtain the contact density map for another sequence
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The protein was expressed and purilied as described (23)
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The three wavelengths yielded the same unfolding curves (data not shown)
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Cell Death Differ 2004; 11:1258-1264(41) Morimoto K, Amano H, Sonoda F, et al
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This view is supported by both the signal amplitude and linewidth in the nucleus with time: Depending on the binding strength, bound molecules would give broad NMR peaks or no signal at all, and the diminazene signal is initially (after 1 h) much smaller than that of aceturate but, after 6 h, reaches ~½ of the aceturate amplitude
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The intrinsic quenching of molecular rotors makes them sensitive to intrinsic rotational relaxation, which is slowed down during binding to aggregated protein
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To determine the activation energy (enthalpy) E^sub a^ [congruent with] ΔH*, the Θ^sub 222^(t) data were fitted by exponentials (Fig
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Among first fibrillar features, short but relatively thick (8-nm) seedlike forms appeared on a very short timescale within the first minute of incubation
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This example serves also to indicate an important qualification-some dimensions clearly do possess funnel-like landscapes even without a projection onto low-dimensional spaces
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This suggests that two slightly different conformational spaces are sampled in the free and complex forms of the molecule, representing a situation of case A (Fig
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They are all believed to be from a single individual because of their proximity and their similar size and shape
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Within the cells clusters of lipid filled vacuoles were apparent and there was limited evidence of collagen fibrils within the pericellular region (Fig
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