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It can retain its activity when subjected to heat treatment at 60°C for 60 min (25), whereas it is irreversibly unfolded when heated at temperatures above 65°C
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Low temperature induced conformational changes of aminoacylase
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Transmission electron microscopyFive microliter aliquots from a TTR misfolding reaction were withdrawn at different time points and were placed on a carbon coated copper grid for 2 min
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