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Effects of glycosylation on peptide conformation: a synergistic experimental and computational study
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In the EV limit, we lind that irrespective of amino acid sequence, internal distances follow the power law predicted by theory for chains in a good solvent
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Then, one is tempted to ask, is there any relationship among the different functions and structures of the PTS proteins on one side, and the thennodynamic parameters and folding properties on the other? To answer this question, it is necessary to describe the conformational preferences of proteins, where studies of different members of the family have been described
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(21) This, however, does not preclude the possibility that some receptors may ultimately be shown to perform both tethering and tickling (signal transduction) functions
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These findings are supported by MD simulations that suggest that the flexibility of protein residues may either decrease or increase upon ligand-binding (9)
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Hence, for any reasonable value of Δ^sup ex^ (up to 6 ppm), these residues are in fast exchange (k^sup -1^^sub ex^ [much greater than] Δω^sub I^)
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, 60%) concentrations of Gβγ on lipid membrane and at supersaturating concentrations of Gβγ are shown in Fig
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Under physiological conditions, insulin is a hexamer, being able to bind two or four Zn^sup 2+^ ions (e
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Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells
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Furthermore, the evolutionary tailoring of nonnative interactions provides additional "design-space" within which a pathway to the folded state may be coded, but without compromising the stability of the final, native state
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Description of posttransition juvenilesThe posttransition juvenile stage was characterized by the acquisition of complete fin-ray complements and by morphological similarities with the adults (Table 3, Fig
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01 kJ K^sup -1^ mol^sup -1^ (solid line in Fig
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In the final stages of vitellogenesis, the largest oocytes were approximately 700 [mu] in diameter and had numerous oil vacuoles and yolk globules throughout the cytoplasm
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diameter = oil globule diameterEgg Reactivity (%)Fish egg diameter O
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A very recent spFRET report on surface-immobilized hairpin ribozymes has also detected a folding intermediate during 4WJ docking (Tan et al
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1973, Errington 1930, Lowe 1980, Raczynski and Ruprecht 1974), most have not (e
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