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These pretransitional conformational changes also resulted in an intermediate with hydrophohic exposure, which could lead to serious aggregation in both chemical denaturants and heat-treatment conditions aura soma .
Although gSBA unfolded via a two-state process without the formation of any unfolding intermedialcs, the denaturation profile of rSBA was poputated with an intermediate (Fig aura soma .
The number and locations of nonnative local contacts that are to be broken determine the sets of spatial contacts that are formed upon folding aura soma .
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1 M^sup -1^) similar to those measured in isolated EI^sup SC^ (Table 1), and smaller when PEP (1 aura soma .
These data reveal an increased flexibility of native HuBChE relative to its soman-inhibited counterpart above 334 K (61°C) aura soma .
Ca^sup 2+^ signaling can inhibit the transcriptional activities in vivo of the bHLH proteins E12 and SEF2-1 through direct binding of Ca^sup 2+^/CaM to the basic sequence of the proteins, resulting in inhibition of their DNA binding (15) aura soma .
Two of the hinge regions are formed by the flexible part of the central helix of the CaM molecules, and the other two hinge regions are formed by the flexible dimerization interfaces aura soma .
Hard-sphere statistics along the metastable amorphous branch aura soma .
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