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. The values of K^sub SV^ for Trp residues in proteins and for free Trp in aqueous solution are not directly comparable
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. Since the major enthalpic contribution ΔH* [congruent with] E^sub a^ to the free energy barrier ΔG* = ΔH*-TΔS* for the disk denaturation may arise from the transient disruption of the predominantly hydrophobic protein-lipid interactions, similar values of E^sub a^ may reflect similar combined hydrophobic surfaces in the amphipathic α-helices in apoA-1 and apoA-2 that are comprised of ~50 amino acids in the lipid-bound state of these proteins
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. This indicated that most of the Trp residues in ACYI were buried in the interior (Class I) or exposed to bonded water (Class II), and no Trp residues were in a highly hydrophobic (Class A and S) or fully solvent-exposed (Class III) microenvironment
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